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\u5ba2\u54e1\u6559\u6388\u3000\u6e21\u8fba\u3000\u548c\u5f66<\/a><\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

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\uff11\uff0e\u80a5\u57f9\u7ba1\u7406<\/h3>\n\n\n\n

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\uff12\uff09\u65bd\u80a5\u306e\u8003\u3048\u65b9<\/h4>\n\n\n\n

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\u3000\u56f3\uff11\u306f\uff0c\u30cf\u30a6\u30b9\u534a\u4fc3\u6210\u9577\u671f\u3069\u308a\u683d\u57f9\u306e\u5b9a\u690d\u5f8c\uff11\u5e74\u9593\u306e\u990a\u5206\u5438\u53ce\u91cf\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u3053\u308c\u3092\u898b\u3066\u308f\u304b\u308b\u3088\u3046\u306b\uff0c\u30a2\u30b9\u30d1\u30e9\u30ac\u30b9\u306f\u7a92\u7d20\u3068\u30ab\u30ea\u306e\u5438\u53ce\u91cf\u304c\u3068\u304f\u306b\u591a\u304f\uff0c\u6b21\u3044\u3067\u30ea\u30f3\u9178\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u3067\u3042\u308a\uff0c\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u91cf\u306f\u3082\u3063\u3068\u3082\u5c11\u306a\u3044\u3002\u307e\u305f\uff0c\u5b9a\u690d\uff11\u5e74\u76ee\u306e\u7a92\u7d20\u5438\u53ce\u91cf\u306f15kg\u304b\u308920kg\u3067\u3042\u308b\u3002\u307e\u305f\uff0c\u830e\u8449\u306e\u898b\u305f\u76ee\u306e\u751f\u80b2\u91cf\u306f\u990a\u5206\u5438\u53ce\u91cf\u3092\u8868\u308f\u3057\uff0c\u751f\u80b2\u306b\u5fdc\u3058\u3066\u5438\u53ce\u91cf\u3082\u5897\u3048\u308b\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\uff13\uff09\u6e1b\u80a5\u51e6\u7406\u3068\u7a92\u7d20\u306e\u9069\u6b63\u65bd\u7528\u91cf<\/h4>\n\n\n\n

\u3000\u3053\u3053\u3067\u30e2\u30df\u30ac\u30e9\u725b\u3075\u3093\u5806\u80a510t\u3092\u6bce\u5e74\u65bd\u7528\u3057\u7d9a\u3051\u305f\u5834\u5408\uff0c\u30ab\u30ea\u30a6\u30e0\u306a\u3069\u304c\u84c4\u7a4d\u3057\uff0c\u5869\u57fa\u30d0\u30e9\u30f3\u30b9\u3082\u60aa\u5316\u3059\u308b\u306e\u3067\uff0c\u5316\u5b66\u80a5\u6599\u3092\u6e1b\u80a5\u3059\u308b\u304b\uff0c\u3082\u3057\u304f\u306f\u5165\u308c\u306a\u3044\u3068\u3044\u3063\u305f\u5bfe\u7b56\u3082\u601d\u3044\u5207\u3063\u3066\u5b9f\u65bd\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n\n\n\n

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\n
\"\"<\/figure><\/div>\n\n\n

\u3000\u3057\u305f\u304c\u3063\u3066\uff0c\u30a2\u30b9\u30d1\u30e9\u30ac\u30b9\u306e\u534a\u4fc3\u6210\u9577\u671f\u3069\u308a\u683d\u57f9\u306b\u304a\u3044\u3066\uff0c\u30e2\u30df\u30ac\u30e9\u725b\u3075\u3093\u5806\u80a510a\u5f53\u305f\u308a10t\uff08\u7a92\u7d20120kg\uff0c\u30ea\u30f3\u9178130kg\uff0c\u30ab\u30ea\u30a6\u30e0150kg\u3092\u542b\u3080\uff09\u3092\u65bd\u7528\u3057\u305f\u5834\u5408\u306e\u9069\u6b63\u306a\u7a92\u7d20\u65bd\u80a5\u91cf\u306f\uff0c10a\u5f53\u305f\u308a40kg\u3068\u3059\u308b\u306e\u304c\uff0c\u30a2\u30b9\u30d1\u30e9\u30ac\u30b9\u306e\u53ce\u91cf\uff0c\u54c1\u8cea\u305d\u3057\u3066\u7d4c\u6e08\u6027\u306e\u9762\u304b\u3089\u9069\u5f53\u3067\u3042\u308d\u3046\u3002<\/p>\n\n\n\n

\u3000\u3053\u306e\u3088\u3046\u306b\u65bd\u80a5\u91cf\u306f\u571f\u58cc\u3084\u5730\u529b\uff0c\u6709\u6a5f\u7269\u7531\u6765\u306b\u3088\u308b\u3082\u306e\u3084\u65bd\u80a5\u6cd5\u306a\u3069\uff0c\u8907\u96d1\u306a\u6761\u4ef6\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u305f\u3081\uff0c\u73fe\u72b6\u306f\u57fa\u6e96\u7684\u306a\u6570\u5b57\u3057\u304b\u6253\u3061\u51fa\u305b\u306a\u3044\u304c\uff0c\u5c11\u306a\u304f\u3068\u3082\u30a2\u30b9\u30d1\u30e9\u30ac\u30b9\u306f\u8c4a\u5bcc\u306a\u6709\u6a5f\u7269\u3068\u591a\u80a5\u3092\u597d\u3080\u91ce\u83dc\u3067\u3042\u308b\u3053\u3068\u306f\u9593\u9055\u3044\u306a\u3044\u3002<\/p>\n\n\n\n

\u3000\u5b9f\u969b\u306e\u683d\u57f9\u73fe\u5834\u3067\u306f\uff0c\u5bb6\u755c\u3075\u3093\u5c3f\u7531\u6765\u306e\u6709\u6a5f\u7269\u306e\u591a\u6295\u5165\uff0c\u591a\u80a5\u96c6\u7d04\u683d\u57f9\u3092\u884c\u306a\u3063\u3066\u3044\u308b\u8fb2\u5bb6\u304c\u591a\u3044\u3002\u5316\u5b66\u80a5\u6599\u306e\u5e74\u9593\u7a92\u7d20\u6210\u5206\u306770\uff5e80kg-N\/10a\u4ee5\u4e0a\u65bd\u7528\u3057\u3066\u3044\u308b\u4f8b\u3082\u3081\u305a\u3089\u3057\u304f\u306a\u3044\u3002<\/p>\n\n\n\n

\u3000\u3053\u308c\u3089\u306e\u6709\u6a5f\u7269\u3084\u80a5\u6599\u306e\u3044\u304d\u3059\u304e\u305f\u6295\u5165\u3092\u6539\u5584\u3057\uff0c\u540c\u6642\u306b\u30a2\u30b9\u30d1\u30e9\u30ac\u30b9\u306e\u751f\u7406\u3068\u80a5\u6599\u306e\u52b9\u7387\u7684\u306a\u5229\u7528\u3092\u8e0f\u307e\u3048\u305f\u65bd\u80a5\u6cd5\u304c\u5927\u5207\u3067\u3042\u308b\u3002<\/p>\n\n\n\n

\u3000\u30a2\u30b9\u30d1\u30e9\u30ac\u30b9\u30cf\u30a6\u30b9\u683d\u57f9\u306e\u65bd\u80a5\u91cf\u306e\u76ee\u5b89\u3092\u8868\uff12\u306b\u793a\u3059\u3002\u3053\u308c\u306f\uff0c\u725b\u3075\u3093\u5806\u80a5\u3092\u6bce\u5e74\u65bd\u7528\u3059\u308b\u3053\u3068\u3092\u524d\u63d0\u3068\u3057\u305f\u3082\u306e\u3067\uff0c\u5b9a\u690d\u524d\u3042\u308b\u3044\u306f\u53ce\u7a6b\u7d42\u4e86\u5f8c\u306e\u571f\u58cc\u5206\u6790\u7d50\u679c\u306b\u57fa\u3065\u3044\u3066\u65bd\u80a5\u91cf\u3092\u52a0\u6e1b\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002\u65bd\u80a5\u6cd5\u3068\u3057\u3066\u306f\u6625\u671f\uff14\u5206\u306e\uff11\uff0c\u590f\u79cb\u671f\uff14\u5206\u306e\uff13\u306e\u5206\u65bd\u304c\u7406\u60f3\u7684\u3067\u3042\u308b\u3002\u307e\u305f\u30a2\u30b9\u30d1\u30e9\u30ac\u30b9\u306f\u597d\u77f3\u7070\u690d\u7269\u3067\u3042\u308b\u305f\u3081\uff0c\u571f\u58ccpH\u306b\u306f\u7559\u610f\u3057\uff0c\u65bd\u7528\u3059\u308b\u77f3\u7070\u8cc7\u6750\u306e\u9078\u629e\u3082\u91cd\u8981\u306a\u30dd\u30a4\u30f3\u30c8\u3068\u306a\u308b\u3002pH\u304c\u4f4e\u3044\u5834\u5408\u306f\u70ad\u30ab\u30eb\u3084\u82e6\u571f\u77f3\u7070\u3092\uff0cpH\u304c\u9069\u6b63\u5024\u306e\u5834\u5408\u306f\u30ab\u30ad\u304c\u3089\u77f3\u7070\u306a\u3069\u3092\u4f7f\u7528\u3059\u308b\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u3000EC\u306f\u6c34\u306b\u6eb6\u3051\u305f\u80a5\u6599\uff08\u4e3b\u306b\u785d\u9178\u614b\u7a92\u7d20\uff09\u306e\u7dcf\u91cf\u3092\u8868\u308f\u3059\u3002\u3053\u306e\u5024\u304c\u9ad8\u3059\u304e\u308b\u5834\u5408\u306f\uff0c\u6fc3\u5ea6\u969c\u5bb3\u3084\u30ac\u30b9\u969c\u5bb3\u3092\u751f\u3058\u308b\u3002\u5bb6\u755c\u3075\u3093\u5c3f\u7531\u6765\u306e\u5806\u80a5\u306a\u3069\u3092\u591a\u91cf\u306b\u65bd\u7528\u3059\u308b\u3068\uff0cEC\u3060\u3051\u3067\u306a\u304f\uff0c\u77f3\u7070\u3084\u30ab\u30ea\u304c\u96c6\u7a4d\u3057\uff0c\u571f\u58ccpH\u304c\u4e0a\u6607\u3059\u308b\u3002\u3053\u306e\u5834\u5408\uff0c\u77f3\u7070\u3084\u30ab\u30ea\u306a\u3069\u3092\u591a\u91cf\u306b\u542b\u3080\u80a5\u6599\u3084\u6709\u6a5f\u7269\u306e\u65bd\u7528\u3092\u4e2d\u6b62\u3059\u308b\u3002EC\u306f\u9ad8\u3059\u304e\u3066\u3082\u4f4e\u3059\u304e\u3066\u3082\u969c\u5bb3\u306e\u51fa\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308b\u3002<\/p>\n\n\n\n

\u3000EC\u304c\u9ad8\u304f\uff0cpH\u304c\u4f4e\u3044\u5834\u5408\u306f\uff0c\u785d\u9178\u614b\u7a92\u7d20\u4ee5\u5916\u306b\u786b\u5316\u7269\u3084\u5869\u5316\u7269\u306e\u96c6\u7a4d\u304c\u7591\u308f\u308c\u308b\u3002\u904e\u53bb\u306b\u65bd\u7528\u3057\u305f\u80a5\u6599\u3084\u6709\u6a5f\u7269\u306e\u7a2e\u985e\u3084\u91cf\u3092\u8003\u3048\u305f\u3046\u3048\u3067\uff0c\u785d\u9178\u614b\u7a92\u7d20\u306e\u5206\u6790\u3092\u884c\u306a\u3044\uff0c\u57fa\u80a5\u7a92\u7d20\u306e\u6e1b\u80a5\u306a\u3069\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308b\u3002EC\u5024\u306b\u3088\u308b\u6b8b\u5b58\u7a92\u7d20\u91cf\u306810a\u5f53\u305f\u308a\u4f9b\u7d66\u91cf\u306e\u95a2\u4fc2\u3092\u8868\uff13\u306b\u793a\u3059\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\uff14\uff09\u8ffd\u80a5<\/h4>\n\n\n\n

\u3000\u4e00\u822c\u7684\u306b\uff0c\u8ffd\u80a5\u3092\u884c\u3046\u5834\u5408\u306f\u65bd\u80a5\u91cf\u3068\u6642\u671f\uff0c\u65bd\u80a5\u4f4d\u7f6e\uff0c\u80a5\u6599\u306e\u5f62\u614b\u306a\u3069\u3092\u7dcf\u5408\u7684\u306b\u8003\u616e\u3059\u308b\u3002<\/p>\n\n\n\n

\u3000\u65bd\u80a5\u91cf\uff1a\uff11\u56de\u5f53\u305f\u308a\u306e\u8ffd\u80a5\u91cf\u306f\u571f\u6027\u3084\u4fdd\u80a5\u529b\u306b\u3088\u308a\u7570\u306a\u308b\u304c\uff0c\u8ffd\u80a5\u3092\u884c\u3046\u305f\u3073\u306b\u91cf\u3092\u5909\u66f4\u3059\u308b\u3053\u3068\u306f\u5c11\u306a\u304f\uff0c\u7a92\u7d20\u6210\u5206\u91cf\u306710a\u5f53\u305f\u308a2\uff5e3kg\u3092\u76ee\u5b89\u3068\u3059\u308b\u3002<\/p>\n\n\n\n

\u3000\u65bd\u80a5\u6642\u671f\uff1a\u8ffd\u80a5\u306e\u958b\u59cb\u6642\u671f\u306f\u57fa\u80a5\u306e\u65bd\u7528\u91cf\u3084\u80a5\u6599\u306e\u5f62\u614b\u306a\u3069\u306b\u3088\u308a\u7570\u306a\u308b\u304c\uff0c\u5b9a\u690d\u5f8c30\uff5e60\u65e5\u304b\u3089\u59cb\u3081\uff0c20\uff5e30\u65e5\u9593\u9694\u3067\u65bd\u7528\u3059\u308b\u3002<\/p>\n\n\n\n

\u3000\u65bd\u80a5\u4f4d\u7f6e\uff1a\u65bd\u80a5\u4f4d\u7f6e\u306f\u5b9a\u690d\u5f8c\u306e\u6839\u306e\u5e83\u304c\u308a\u306b\u5fdc\u3058\u3066\u5909\u3048\u308b\u3002\uff11\u5e74\u751f\u682a\u306e\u8ffd\u80a5\u306f\u8868\u5c64\u65bd\u80a5\u3084\u6df1\u5c64\u65bd\u80a5\u304c\u4e00\u822c\u7684\u3067\u3042\u308b\u3002<\/p>\n\n\n\n

\u3000\u8868\u5c64\u65bd\u80a5\u306f\uff0c\u80a5\u6599\u306e\u6d41\u4ea1\u304c\u591a\u3044\u3082\u306e\u306e\u751f\u80b2\u306b\u5fdc\u3058\u305f\u65bd\u80a5\u304c\u53ef\u80fd\u3067\u3042\u308a\uff0c\u80a5\u52b9\u3082\u65e9\u304f\uff0c\u65bd\u80a5\u4f5c\u696d\u3082\u5bb9\u6613\u306a\u305f\u3081\uff0c\u6700\u3082\u4e00\u822c\u7684\u3067\u3042\u308b\u3002\u5b9a\u690d\u521d\u671f\u306f\u682a\u306e\u5468\u8fba\u306b\u884c\u306a\u3044\uff0c\u830e\u8449\u306e\u7e41\u8302\u306b\u3068\u3082\u306a\u3063\u3066\u3046\u306d\u9762\u5168\u4f53\u306b\u65bd\u7528\u3059\u308b\u3002<\/p>\n\n\n\n

\u3000\u571f\u58cc\u6df1\u5c64\u3078\u306e\u6db2\u80a5\u704c\u6ce8\u65bd\u80a5\u306f\u80a5\u52b9\u304c\u9ad8\u304f\uff0c\u80a5\u52b9\u304c\u6301\u7d9a\u3057\uff0c\u751f\u80b2\u91cf\u3084\u53ce\u91cf\u3092\u9ad8\u3081\u308b\u52b9\u679c\u304c\u9ad8\u3044\uff08\u8868\uff14)\u3002\u4e00\u822c\u7684\u306b\uff0c\u571f\u58cc\u6fef\u6ce8\u6a5f\u306a\u3069\u3092\u7528\u3044\u3066\u830e\u8449\u304c\u7e41\u8302\u3057\u305f\u9803\u304b\u3089\u884c\u3046\u3002
\u3000\u80a5\u6599\u306e\u5f62\u614b\uff1a\u80a5\u52b9\u306e\u767a\u73fe\u306e\u65e9\u3044\u901f\u52b9\u6027\u80a5\u6599\u3092\u65bd\u7528\u3059\u308b\u5834\u5408\uff0c\u65bd\u80a5\u91cf\u3092\u6e1b\u3089\u3057\u3066\u6839\u50b7\u307f\u3092\u9632\u3050\u3068\u3068\u3082\u306b\uff0c\u65bd\u80a5\u306e\u9593\u9694\u306b\u3082\u6ce8\u610f\u3059\u308b\u3002\u7de9\u52b9\u6027\u80a5\u6599\u3067\u306f\uff0c\u80a5\u52b9\u306e\u767a\u73fe\u304c\u9045\u5ef6\u3057\u306a\u3044\u3088\u3046\u704c\u6c34\u306b\u6ce8\u610f\u3059\u308b\u3002\u80a5\u52b9\u306e\u6301\u7d9a\u6027\u306f\u65bd\u80a5\u306e\u4f5c\u696d\u52b9\u7387\u3068\u306e\u95a2\u4fc2\u304c\u6df1\u304f\uff0c\u80a5\u52b9\u306e\u6301\u7d9a\u304c\u9577\u3044\u307b\u3069\u8ffd\u80a5\u9593\u9694\u306f\u5e83\u304f\u306a\u308a\uff0c\u4f5c\u696d\u52b9\u7387\u304c\u9ad8\u307e\u308b\u3002\u307e\u305f\u704c\u6c34\u30c1\u30e5\u30fc\u30d6\u306b\u3088\u308b\u6db2\u80a5\u306e\u6d41\u3057\u8fbc\u307f\u65bd\u80a5\u306f\u7701\u529b\u7684\u3067\uff0c\u80a5\u52b9\u304c\u65e9\u3044\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\uff15\uff09\u80a5\u52b9\u8abf\u7bc0\u578b\u80a5\u6599<\/h4>\n\n\n\n

\u3000\u30a2\u30b9\u30d1\u30e9\u30ac\u30b9\u306e\u65bd\u80a5\u3067\u306f\uff0c\u901f\u52b9\u6027\u80a5\u6599\u3092\u7528\u3044\u305f\u65bd\u80a5\u9593\u9694\u306e\u77ed\u3044\u65bd\u80a5\u4f53\u7cfb\u304c\u3068\u3089\u308c\u3066\u3044\u305f\u304c\uff0c\u6700\u8fd1\u306f\u590f\u5834\u306e\u9023\u7d9a\u65bd\u80a5\uff08\u8ffd\u80a5\uff09\u4f5c\u696d\u306e\u7701\u529b\u5316\u3092\u76ee\u7684\u3068\u3057\uff0c\u304b\u3064\u990a\u5206\u5438\u53ce\u30d1\u30bf\u30fc\u30f3\u306b\u5bfe\u5fdc\u3057\u305f\u65bd\u80a5\u6cd5\u3068\u3057\u3066\uff0c\u80a5\u52b9\u8abf\u7bc0\u578b\u80a5\u6599\u306e\uff11\u56de\u65bd\u80a5\u304c\u884c\u306a\u308f\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n

\u3000\u80a5\u52b9\u8abf\u7bc0\u578b\u80a5\u6599\u3082\u7528\u3044\u305f\u5168\u91cf\u57fa\u80a5\u65bd\u80a5\u6cd5\u306f\u4e2d\u9593\u8ffd\u80a5\u3092\u7701\u7565\u3057\uff0c\u8fb2\u5bb6\u306e\u624b\u9593\u3092\u7701\u304f\u65bd\u80a5\u6cd5\u3067\u3042\u308a\uff0c\u3053\u308c\u307e\u3067\u306e\u65bd\u80a5\u6cd5\u3092\u4e00\u65b0\u3055\u305b\u305f\u3002\u307e\u305f\uff0c\u4f5c\u7269\u6839\u306b\u3088\u308a\u8fd1\u3044\u5834\u6240\u306b\u63a5\u89e6\u65bd\u80a5\u3092\u884c\u3046\u3053\u3068\u3067\uff0c\u80a5\u6599\u306e\u5229\u7528\u7387\u3092\u3088\u308a\u9ad8\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3002<\/p>\n\n\n\n

\u3000\u901f\u52b9\u6027\u80a5\u6599\u306e\u8ffd\u80a5\u4f53\u7cfb\u3067\u306f\u80a5\u6599\u6210\u5206\u304c\u6025\u6fc0\u306b\u6eb6\u51fa\u3057\uff0c\u4f5c\u7269\u306e\u5438\u53ce\u304c\u8ffd\u3044\u3064\u304b\u305a\uff0c\u571f\u58cc\u4e2d\u3067\u306f\u7121\u6a5f\u990a\u5206\u304c\u9ad8\u6fc3\u5ea6\u3067\u63a8\u79fb\u3059\u308b\u3002\u3057\u304b\u3057\uff0c\u5f90\u3005\u306b\u6eb6\u51fa\u3059\u308b\u80a5\u52b9\u8abf\u7bc0\u578b\u80a5\u6599\u306e\u5834\u5408\uff0c\u9a5a\u304f\u307b\u3069\u4f4e\u6fc3\u5ea6\u3067\u63a8\u79fb\u3057\uff0c\u96c6\u7a4d\u306f\u8a8d\u3081\u3089\u308c\u306a\u3044\u3002\u3053\u306e\u3088\u3046\u306b\uff0c\u80a5\u52b9\u8abf\u7bc0\u578b\u80a5\u6599\u306e\u5168\u91cf\u57fa\u80a5\u65bd\u80a5\u6cd5\u306f\u8ffd\u80a5\u4f5c\u696d\u306e\u7701\u529b\u5316\u3060\u3051\u3067\u306a\u304f\uff0c\u7a92\u7d20\u4f9b\u7d66\u91cf\u3092\u7bc0\u6e1b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\uff0c\u5869\u985e\u96c6\u7a4d\u304c\u8efd\u6e1b\u3055\u308c\u308b\u74b0\u5883\u4fdd\u5168\u578b\u306e\u65bd\u80a5\u6cd5\u3067\u3042\u308b\u3002<\/p>\n\n\n\n

\uff12\uff0e\u704c\u6c34\u7ba1\u7406<\/h3>\n\n\n\n

\u3000\uff11\u5e74\u751f\u682a\u306e\u704c\u6c34\u306f\uff0c\u5730\u4e0a\u90e8\u3068\u5730\u4e0b\u90e8\u306e\u751f\u80b2\u306b\u5927\u304d\u304f\u5f71\u97ff\u3059\u308b\u3002\u8868\uff15\u306b\u793a\u3059\u3088\u3046\u306b\uff0c\u571f\u58cc\u6c34\u5206\u304c\u591a\u3044\u307b\u3069\u308a\u3093\u82bd\u6570\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304b\u3089\uff0c\u5730\u4e0b\u830e\u306e\u9069\u5ea6\u306a\u571f\u58cc\u6c34\u5206\u306f\u840c\u82bd\u3060\u3051\u3067\u3001\u306a\u304f\u767a\u6839\u3082\u4fc3\u9032\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u3000\u571f\u58cc\u6c34\u5206\u304c\u591a\u3044\u5834\u5408\u306e\u5730\u4e0a\u90e8\u306e\u751f\u80b2\u306f\uff0c\u5074\u679d\u3084\u304e\u8449\u304c\u9577\u304f\u306a\u3063\u3066\u830e\u8449\u304c\u7e41\u8302\u3059\u308b\u3002\u307e\u305f\uff0c\u5730\u4e0b\u90e8\u306e\u751f\u80b2\u3082\u4fc3\u9032\u3055\u308c\u6839\u91cd\u304c\u5897\u52a0\u3059\u308b\u3002<\/p>\n\n\n\n

\u3000\u704c\u6c34\u3092\u884c\u3046\u5834\u5408\u306f\uff0c\u704c\u6c34\u306e\u91cf\u3084\u6642\u671f\uff0c\u704c\u6c34\u3059\u308b\u4f4d\u7f6e\uff0c\u7528\u6c34\u306a\u3069\u3092\u7dcf\u5408\u7684\u306b\u8003\u616e\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/p>\n\n\n\n

\u3000\u704c\u6c34\u91cf\uff1a\u704c\u6c34\u91cf\u306f\u682a\u306e\u751f\u80b2\u91cf\u3084\u6c17\u8c61\u306a\u3069\u3092\u8003\u616e\u3057\u3066\u6c7a\u3081\u308b\u3002\u751f\u80b2\u91cf\u304c\u591a\u304f\u306a\u308b\u307b\u3069\uff0c\u6c17\u6e29\u3084\u65e5\u5c04\u91cf\u304c\u5897\u52a0\u3059\u308b\u307b\u3069\u704c\u6c34\u91cf\u3092\u5897\u3084\u3059\u3002\uff11\u5e74\u751f\u682a\u306e\u682a\u990a\u6210\u671f\u9593\u4e2d\u306f\u704c\u6c34\u91cf\u304c\u591a\u3044\uff08\uff1d\u704c\u6c34\u3067\u304d\u308b\uff1d\u6392\u6c34\u6027\u304c\u826f\u3044\uff09\u307b\u3069\u5b9a\u690d\u521d\u5e74\u76ee\u306e\u751f\u80b2\u3068\u7fcc\u5e74\u306e\u6625\u82bd\u306e\u53ce\u91cf\u304c\u512a\u308c\u308b\u3002<\/p>\n\n\n\n

\u3000\u704c\u6c34\u306e\u9593\u9694\u3068\u6642\u9593\u5e2f\uff1a\u704c\u6c34\u306e\u9593\u9694\u306f\u571f\u6027\u3084\u6392\u6c34\u6027\uff0c\u3046\u306d\u306e\u5927\u304d\u3055\u3084\u9ad8\u3055\u306a\u3069\u3067\u7570\u306a\u308b\u3002pF\u5024\u30671.5\uff5e1.8\u306e\u571f\u58cc\u6c34\u5206\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u304c\uff0c\u5168\u4f53\u7684\u306b\u3046\u306d\u8868\u9762\u304c\u4e7e\u3044\u305f\u3089\u704c\u6c34\u3059\u308c\u3070\u3088\u3044\u3002\u3068\u304d\u3069\u304d\u8868\u571f\u3092\u5265\u3044\u3067\u6839\u57df\u306e\u571f\u58cc\u6c34\u5206\u3092\u78ba\u8a8d\u3057\uff0c\u6c34\u306e\u3084\u308a\u3059\u304e\u306b\u6ce8\u610f\u3059\u308b\u3002\u5b89\u5b9a\u3057\u305f\u571f\u58cc\u6c34\u5206\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u306f\uff0c\uff11\u56de\u5f53\u305f\u308a\u306e\u704c\u6c34\u91cf\u3092\u5927\u5e45\u306b\u5897\u3084\u3059\u3088\u308a\u3082\u704c\u6c34\u9593\u9694\u3067\u571f\u58cc\u6c34\u5206\u3092\u8abf\u7bc0\u3059\u308b\u307b\u3046\u304c\u671b\u307e\u3057\u3044\u3002<\/p>\n\n\n\n

\u3000\u704c\u6c34\u3059\u308b\u6642\u9593\u5e2f\u306f\uff0c\u901a\u5e38\u6674\u5929\u65e5\u306e\u5348\u524d\u4e2d\u3068\u3059\u308b\u304c\uff0c\u590f\u5834\u306f\u5730\u6e29\u3092\u4e0b\u3052\u308b\u305f\u3081\u306b\u5915\u65b9\u306b\u884c\u3046\u3068\u3088\u3044\u3002<\/p>\n\n\n\n

\u3000\u306a\u304a\uff0c\u830e\u8449\u306e\u751f\u80b2\u91cf\u304c\u4f4e\u4e0b\u3059\u308b\u79cb\u671f\u4ee5\u964d\u3082\uff0c\u830e\u8449\u306e\u9ec4\u5316\u304c\u9032\u884c\u3059\u308b\u307e\u3067\uff11\uff5e\uff12\u9031\u9593\u306b\uff11\u56de\u7a0b\u5ea6\u306f\u704c\u6c34\u3059\u308b\u3053\u3068\u3067\uff0c\u7fcc\u5e74\u306e\u6625\u82bd\u306e\u53ce\u91cf\u304c\u5897\u52a0\u3059\u308b\uff08\u56f3\uff12)\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u3000\u704c\u6c34\u4f4d\u7f6e\u3068\u65b9\u6cd5\uff1a\u704c\u6c34\u65b9\u6cd5\u306b\u306f\uff0c\u704c\u6c34\u3059\u308b\u4f4d\u7f6e\u306b\u3088\u308a\u8868\u9762\u704c\u6c34\u3084\u3046\u306d\u9593\u704c\u6c34\u304c\u3042\u308b\u3002\u5730\u4e0b\u830e\u304c\u4e7e\u71e5\u3059\u308b\u3068\uff0c\u82e5\u830e\u306e\u840c\u82bd\u6570\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3068\u3082\u306b\u5730\u4e0b\u830e\u306e\u62e1\u5927\u3092\u963b\u5bb3\u3057\uff0c\u65b0\u6839\u306e\u767a\u751f\u6570\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3002\u305d\u306e\u305f\u3081\uff0c\u5b9a\u690d\u5f8c\u306e\u751f\u80b2\u521d\u671f\u306b\u306f\u682a\u5143\u3092\u4e2d\u5fc3\u306b\u704c\u6c34\u3092\u884c\u3046\u3002<\/p>\n\n\n\n

\u3000\u8868\u9762\u704c\u6c34\u306f\u830e\u67af\u75c5\u3092\u8a98\u767a\u3059\u308b\u5371\u967a\u6027\u304c\u3042\u308b\u304c\uff0c\u30a2\u30b9\u30d1\u30e9\u30ac\u30b9\u306e\u751f\u80b2\u306b\u5fdc\u3058\u3066\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u3046\u306d\u9593\u704c\u6c34\u306f\u591a\u91cf\u306e\u6c34\u3092\u5fc5\u8981\u3068\u3059\u308b\u304c\uff0c\u5703\u5834\u5168\u4f53\u306e\u704c\u6c34\u30e0\u30e9\u3092\u9632\u6b62\u3057\u3066\u751f\u80b2\u3092\u5747\u4e00\u5316\u3059\u308b\u52b9\u679c\u304c\u3042\u308b\u3002<\/p>\n\n\n\n

\u3000\u7528\u6c34\u306e\u78ba\u4fdd\uff1a\u704c\u6c34\u3059\u308b\u7528\u6c34\u306f\u6cb3\u5ddd\u6c34\u304b\u4e95\u6238\u6c34\u3067\u3042\u308b\u3002\u3044\u305a\u308c\u306e\u7528\u6c34\u3067\u3082\u3088\u3044\u304c\uff0c\u5468\u5e74\u5b89\u5b9a\u3057\u3066\u4f9b\u7d66\u3067\u304d\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u3068\u304f\u306b\u9ad8\u6e29\u591a\u65e5\u7167\u6642\u306e\u7528\u6c34\u91cf\u306e\u4e0d\u8db3\u306f\uff0c\u682a\u306e\u751f\u80b2\u3092\u6291\u5236\u3057\u6e1b\u53ce\u3092\u307e\u306d\u304f\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u785d\u9178\u5869\u306f\u4eba\u4f53\u306b\u6bd2\u3067\u306f\u306a\u304f\u6709\u76ca<\/h2>\n\n\n\n

\u6771\u4eac\u8fb2\u696d\u5927\u5b66
\u5ba2\u54e1\u6559\u6388\u3000\u6e21\u8fba\u3000\u548c\u5f66<\/p>\n\n\n\n

Introduction<\/h3>\n\n\n\n

\u3000\u300c\u785d\u9178\u5869\u304c\u6709\u5bb3\u3067\u306a\u3044\u306e\u306f\u307e\u3060\u3057\u3082\uff0c\u4e9c\u785d\u9178\u3082\u6709\u5bb3\u3067\u306a\u3044\u3068\u306f\u4fe1\u3058\u3089\u308c\u306a\u3044\u300d\u79c1\u306e\u89aa\u3057\u3044\u571f\u58cc\u80a5\u6599\u5c02\u9580\u5bb6\u306e\u8a00\u8449\u3067\u3042\u308b\u3002\u300c\u571f\u3068\u80a5\u6599\u306e\u65b0\u77e5\u8b58\u300d\uff082012\u5e74\uff0c\u8fb2\u6587\u5354\u767a\u884c\uff09\u3092\u8aad\u3093\u3067\u3044\u305f\u3060\u304d\u305f\u3044\u306e\u3060\u304c\uff0c\u672c\u518a\u5b50\u3082\u305c\u3072\u8aad\u3093\u3067\u3044\u305f\u3060\u304d\u305f\u3044\u3002\u5b66\u554f\u306e\u4e16\u754c\u306f\u65e5\u9032\u6708\u6b69\u3067\u3042\u308b\u3002\u4e00\u822c\u306e\u65b9\u306b\u3082\u3060\u304c\uff0c\u307e\u305a\u571f\u58cc\u80a5\u6599\u306e\u4ef2\u9593\u306e\u4eba\u3005\u306b\u785d\u9178\u5869\u3084\uff0c\u4e9c\u785d\u9178\u5869\u304c\u4e16\u754c\u7684\u306b\u3082\u4eba\u9593\u306b\u5bfe\u3057\u3066\u306f\u6709\u76ca\u306a\u3082\u306e\u3068\u898b\u89e3\u304c\u5927\u304d\u304f\u5909\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u77e5\u3063\u3066\u3044\u305f\u3060\u304d\u305f\u3044\u3002\uff08\u6ce8\uff1a\u53cd\u82bb\u52d5\u7269\u3067\u3042\u308b\u725b\u306f\u7570\u306a\u308b\u3002\u7b2c\u4e00\u80c3\u3067\u3042\u308b\u53cd\u82bb\u80c3\u3078\u5927\u91cf\u306e\u785d\u9178\u5869\u304c\u5165\u308b\u3068\u5fae\u751f\u7269\u306e\u4f5c\u7528\u3067\u4e9c\u785d\u9178\u5869\u3082\u5927\u91cf\u306b\u3067\u304d\u308b\u305f\u3081\uff0c\u725b\u306f\u30e1\u30c8\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u8840\u75c7\u3092\u8d77\u3053\u3057\u3084\u3059\u3044\u3002\u3057\u304b\u3057\uff0c\u4eba\u9593\u306e\u80c3\u306f\u725b\u3068\u306f\u7570\u306a\u308a\uff0c\u4e9c\u785d\u9178\u306f\u6025\u901f\u306b\u4e00\u9178\u5316\u7a92\u7d20\u306b\u5909\u63db\u3055\u308c\u308b\u3002\uff09<\/p>\n\n\n\n

\u3000\u3053\u3053\u3067\u306f\uff0c\u524d\u8a18\u56f3\u66f8\u306b\u8a18\u8f09\u3057\u3066\u3044\u306a\u3044\u77e5\u898b\u3092\u7d39\u4ecb\u3059\u308b\u3002\u785d\u9178\u5869\u306b\u5bfe\u3059\u308b\u8003\u3048\u65b9\u304c\u5927\u304d\u304f\u5909\u308f\u3063\u305f\u306e\u306f1994\u5e74\u304b\u3089\u3067\u3042\u308b\u3002<\/p>\n\n\n\n

\uff12\uff0e\u30fc\u9178\u5316\u7a92\u7d20\u306f\u91ce\u83dc\u3092\u98df\u3079\u308b\u3068\u80c3\u306e\u4e2d\u3067\u5927\u767a\u751f\u3059\u308b<\/h3>\n\n\n\n

\u3000\u30a4\u30b0\u30ca\u30ed\u3089\u306e1998\u5e74\u306e\u30ce\u30fc\u30d9\u30eb\u8cde\u7814\u7a76\uff0c\u4e00\u9178\u5316\u7a92\u7d20\uff08\u4ee5\u4e0bNO\u3068\u3059\u308b\uff09\u306e\u767a\u898b\u3068\u305d\u306e\u4eba\u4f53\u5185\u3067\u306e\u4f5c\u7528\u6a5f\u4f5c\u306e\u767a\u898b\u306b\u95a2\u9023\u3059\u308b\u306e\u3060\u304c\uff0c\u5f53\u521d\u306fNO\u306f\u56f3\uff11\u306b\u793a\u3059\u3088\u3046\u306b\u30a2\u30df\u30ce\u9178\u3067\u3042\u308bL-\u30a2\u30eb\u30ae\u30cb\u30f3\u304b\u3089\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20\uff08NOS\uff09\u306e\u4f5c\u7528\u306b\u3088\u3063\u3066\u751f\u6210\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u305f\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u3000\u3068\u3053\u308d\u304c\u4eca\u3067\u306f\u91ce\u83dc\u7b49\u306e\u98df\u4e8b\u304b\u3089\u6442\u53d6\u3059\u308b\u785d\u9178\u5869\u306f\uff0c\uff08\u6ce8\uff1b\u672c\u7a3f\u3067\u306f\u785d\u9178\u5869\u306f\u785d\u9178\u614b\u7a92\u7d20\uff0c\u785d\u9178\u30a4\u30aa\u30f3\u3068\u540c\u7fa9\u3068\u3057\u3066\u7528\u3044\u308b\uff09\u56f3\uff12\u306b\u793a\u3059\u3088\u3046\u306bNO\u306fNOS\u304c\u6d3b\u6027\u5316\u3067\u304d\u306a\u3044\u3068\u3053\u308d\u3067\u306f\u785d\u9178\u5869\u304cNO\u306e\u4e3b\u305f\u308b\u4f9b\u7d66\u6e90\u306b\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u3000\u307e\u305a\u6700\u521d\u306e\u5927\u767a\u898b\u306f\u30b9\u30a6\u30a7\u30fc\u30c7\u30f3\u306e\u7814\u7a76\u8005Lundberg\u3089\uff081994\uff09\u3067\u3042\u308b\u3002\u30ec\u30bf\u30b9\u3092\u98df\u3079 \uff15\u5206\u5f8c\u306e\u4eba\u9593\u306e\u80c3\u306e\u4e2d\u306b\u306f\uff0c\u547c\u6c17\u306b\u542b\u307e\u308c\u308b100\u500d\u4ee5\u4e0a\u306eNO\u304c\u767a\u751f\u3057\u3066\u3044\u305f\uff08\u56f3\uff13)\u3002\u80c3\u9178\u904e\u591a\u306e\u60a3\u8005\u3055\u3093\u306b\u826f\u304f\u7528\u3044\u3089\u308c\u308b\u30d7\u30ed\u30c8\u30f3\u30dd\u30f3\u30d7\u963b\u5bb3\u5264\u3067\u3082\u3042\u308bOPZ\u3092\u5b9f\u9a13\u958b\u59cb24\u6642\u9593\u524d\u306b\u6295\u4e0e\u3057\u3066\u3044\u308b\u3068\uff0c\u540c\u69d8\u306b\u5b9f\u9a13\u3057\u3067\u3082NO\u306f\u5c11\u3057\u3057\u304b\u691c\u51fa\u3055\u308c\u306a\u3044\u3002\u30d7\u30ed\u30c8\u30f3\u306f\u6c34\u7d20\u30a4\u30aa\u30f3H\u207a\u306e\u3053\u3068\u3060\u304c\uff0cOPZ\u3092\u98f2\u3093\u3067\u3044\u308b\u3068\u80c3\u9178\u306e\u653e\u51fa\u304c\u6291\u5236\u3055\u308c\uff0c\u80c3\u306epH\u304c\u5c11\u3057\u9ad8\u304f\u306a\u308b\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u3000\u305d\u3053\u3067\uff0cin vitro\u5b9f\u9a13\u3092\u5b9f\u65bd\u3057\u305f\u306e\u304c\u56f3\uff14\u3067\u3042\u308b\u3002\u5f53\u521d\u306f\u553e\u6db2\u3082\u5165\u308c\u3066\u3044\u305f\u304c\uff0c\u56f3\uff14\u306e\u53f3\u306b\u793a\u3059\u3088\u3046\u306b\u4e9c\u785d\u9178\u5869\u3060\u3051\u3092pH1.0\u306e\u5869\u9178\u6eb6\u6db2\u4e2d\u306b\u5165\u308c\u3067\u3082NO\u304c\u767a\u751f\u3059\u308b\u3002\u3059\u306a\u308f\u3061\uff0c\u80c3\u306e\u4e2d\u306e\u3088\u3046\u306a\u4f4epH\u4e0b\u3067\u306f\u975e\u9175\u7d20\u7684\u306b\u4e9c\u785d\u9178\u5869\u304b\u3089NO\u304c\u767a\u751f\u3059\u308b\u4e8b\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\uff13\uff0e\u785d\u9178\u5869\u3092\u6442\u53d6\u3059\u308b\u3068\u80c3\u6f70\u760d\u306b\u306a\u308a\u306b\u304f\u3044<\/h3>\n\n\n\n

\u3000\u3042\u308b\u7a2e\u306e\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u6027\u6297\u708e\u75c7\u5264\uff08NSAID\uff09\u306f\u526f\u4f5c\u7528\u3068\u3057\u3066\u80c3\u6f70\u760d\u306b\u306a\u308a\u3084\u3059\u3044\u3002\u30e9\u30c3\u30c8\u306bNSAID\u3092\u6295\u4e0e\uff11\u9031\u9593\u524d\u304b\u3089\uff0c\u56f3\uff15\u306b\u793a\u3059\u3088\u3046\u306b\u901a\u5e38\u306e\u98df\u990c\u4ee5\u5916\u306b\u785d\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\u3092\u4f53\u91cd\uff11kg\u3042\u305f\u308a\uff11\u65e5\u6442\u53d6\u91cf0.1mmol\uff0c1mmol\u306b\u306a\u308b\u3088\u3046\u98f2\u6599\u6c34\u3067\u4e0e\u3048\u305f\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u533a\u306f\u5869\u5316\u30ca\u30c8\u30ea\u30a6\u30e0\u30921mmol\u4e0e\u3048\u3066\u3044\u308b\u3002\u305d\u3057\u3066\uff0cNSAID\u6295\u4e0e\uff14\u6642\u9593\u5f8c\u306b\u80c3\u6f70\u760d\u306e\u7a0b\u5ea6\u3092\u8abf\u67fb\u3057\u305f\u306e\u304c\u56f3\uff15\u3067\u3042\u308b\u3002\u785d\u9178\u5869\u306e\u6442\u53d6\u306f\u80c3\u6f70\u760d\u306e\u75c7\u72b6\u3092\u8efd\u3044\u3082\u306e\u306b\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u3000\u785d\u9178\u5869\u6442\u53d6\u304c\u80c3\u6f70\u760d\u75c7\u72b6\u3092\u8efd\u6e1b\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3082\u5206\u304b\u3063\u3066\u3044\u308b\u3002\u56f3\uff16\u306b\u793a\u3059\u3088\u3046\u306b\u9ad8\u6fc3\u5ea6\u306e\u4e9c\u785d\u9178\u5869\u304c\u80c3\u5185\u306b\u5165\u308b\u3068\uff0c\u80c3\u7c98\u819c\u306e\u8840\u6d41\u304c\u3088\u304f\u306a\u308b\u3002\u305d\u3057\u3066\u80c3\u7c98\u6db2\u306e\u5206\u6ccc\u3082\u591a\u304f\u306a\u308b\u3002\u8840\u6d41\u304c\u826f\u304f\u306a\u308b\u7406\u7531\u306f\u56f3\uff11\u3092\u7528\u3044\u3066\u300c\u571f\u3068\u65bd\u80a5\u306e\u65b0\u77e5\u8b58\u300d\u3067\u8a73\u3057\u304f\u8aac\u660e\u3057\u3066\u3044\u308b\u3002NO\u304c\u56f3\u306b\u793a\u3059\u3088\u3046\u306b\u30b5\u30a4\u30af\u30ea\u30c3\u30afGMP\u5408\u6210\u3092\u6d3b\u767a\u306b\u3059\u308b\u3002\u305d\u308c\u304c\uff0c\u8840\u7ba1\u5185\u90e8\u306e\u5e73\u6ed1\u7b4b\u3092\u5f1b\u7de9\u3059\u308b\u4f5c\u7528\u304c\u3042\u308b\u305f\u3081\u8840\u7ba1\u304c\u5e83\u304c\u308a\uff0c\u8840\u6d41\u304c\u6d41\u308c\u3084\u3059\u304f\u306a\u308b\u3002\u80c3\u306e\u4e2d\u3067\u3082\u540c\u69d8\u306b\uff0c\u80c3\u7c98\u819c\u306e\u5e73\u6ed1\u7b4b\u306bNO\u304c\u4f5c\u7528\u3059\u308b\u3068\uff0c\u80c3\u7c98\u819c\u306e\u8840\u7ba1\u304c\u5e83\u304c\u308a\uff0c\u8840\u6db2\u304c\u6d41\u308c\u3084\u3059\u304f\u306a\u308a\uff0c\u591a\u304f\u306e\u9178\u7d20\u304c\u4e0e\u3048\u3089\u308c\u80c3\u306e\u6d3b\u52d5\u304c\u6d3b\u767a\u5316\u3059\u308b\u306e\u3067\u3042\u308b\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

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\u3000\u4eba\u9593\u3067\u306e\u5b9f\u9a13\u4f8b\u3092\u3053\u3053\u3067\u306f2\u3064\u7d39\u4ecb\u3059\u308b\u3002\u4e00\u3064\u306f\uff0c\u5065\u5eb7\u306a\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u5e73\u5747\u5e74\u9f6224\u6b73\u306e\u7537\u5b5015\u540d\u5973\u6027\uff12\u540d\u3067\u306e\u5b9f\u9a13\u3067\u3042\u308b\u3002\u91ce\u83dc\u6442\u53d6\u306e\u591a\u3044\u98df\u4e8b\u306b\u542b\u307e\u308c\u308b\u785d\u9178\u5869\u3068\u307b\u307c\u540c\u3058\u91cf\u3092\u785d\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\u3067\u30010.1mmol\/kg\/\u65e5\uff0c\uff13\u65e5\u9593\u6442\u53d6\u3059\u308b\u3068\uff0c\u56f3\uff17\u306b\u793a\u3059\u3088\u3046\u306b\u5065\u5eb7\u4eba\u306e\u6700\u5c0f\u8840\u5727\uff08\u62e1\u5f35\u671f\u8840\u5727\uff09\u304c\uff5e3.5mmHg\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3002\u6700\u9ad8\u8840\u5727\uff08\u53ce\u7e2e\u671f\u8840\u5727\uff09\u306f\u5909\u5316\u306a\u3057\u3068\u306e\u7d50\u679c\u3092\u5f97\u3066\u3044\u308b\uff09Larsen et al\uff0e2006)\u3002<\/p>\n\n\n\n

\u3000\u6442\u53d6\u3057\u305f\u785d\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\u306f\uff0c\u4f53\u91cd60kg\u3068\u3059\u308b\u3068\uff0cN\u306784mg\/\u65e5\uff0cNaNO3<\/sub>\u3067\u30010.5g\/\u65e5\u3068\u306a\u308b\u3002\u53c2\u8003\u306b\u3057\u305f\u3044\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u3000\u3082\u3046\u4e00\u3064\u306e\u4f8b\u306f\uff0c\u785d\u9178\u5869\u3092\u7d0445mmol\/L\uff08N\uff1a630ppm\uff0cNO3<\/sub>\uff1a2790ppm\uff09\u542b\u3080\u30d3\u30fc\u30c8\u30b8\u30e5\u30fc\u30b9500ml\u3092\u5065\u5eb7\u306a\u88ab\u9a13\u8005\u304c\u98f2\u7528\u3057\u305f\u5f8c\u306e\u7d4c\u904e\u6642\u9593\u3054\u3068\u306e\uff0c\u8840\u6f3f\u4e2d\u306e\u785d\u9178\u5869\uff08a)\uff0c\u4e9c\u785d\u9178\u5869\uff08b)\u306e\u6fc3\u5ea6\u5909\u5316\u3092\u8abf\u3079\u305f\u3082\u306e\u3067\u3042\u308b\u3002\u56f3\uff18\u306b\u793a\u3059\u3088\u3046\u306b\u98f2\u7528\u3057\u306a\u3044\u4eba\u306e\u8840\u6f3f\u4e2d\u785d\u9178\u5869\uff0c\u4e9c\u785d\u9178\u5869\u306e\u5897\u52a0\u306f\u8a8d\u3081\u3089\u308c\u306a\u3044\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u3000\u30d3\u30fc\u30c8\u30b8\u30e5\u30fc\u30b9\u306f\u65e5\u672c\u3067\u306f\u306a\u3058\u307f\u304c\u5c11\u306a\u3044\u304c\uff0c\u30d3\u30fc\u30c8\u306f\u8d64\u30ab\u30d6\u306e\uff11\u7a2e\u3067\u30b8\u30e5\u30fc\u30b9\u306e\u8272\u306f\u8d64\u3044\u3002\u8272\u306f\u7570\u306a\u308b\u304c\uff0c\u30c0\u30a4\u30b3\u30f3\u304a\u308d\u3057\u306e\u6c41\u3068\u30a4\u30e1\u30fc\u30b8\u4e0b\u3055\u308c\u3070\u826f\u3044\u3002\u30d3\u30fc\u30c8\u6839\u306f\u30db\u30a6\u30ec\u30f3\u30bd\u30a6\u4e26\u306e\u785d\u9178\u5869\u542b\u6709\u7387\u304c\u3042\u308b\u3002\u30d3\u30fc\u30c8\u6839\u306b\u306f\u52a3\u308b\u304c\uff0c\u30c0\u30a4\u30b3\u30f3\u306e\u785d\u9178\u5869\u542b\u6709\u7387\u3082\u610f\u5916\u3068\u9ad8\u3044\u3002<\/p>\n\n\n\n

\u3000\u56f3\uff18\u306ec\u3068d\u306f\u540c\u3058\u304f\u8840\u6f3f\u4e2d\u306e\u785d\u9178\u5869\u3068\u4e9c\u785d\u9178\u5869\u6fc3\u5ea6\u3067\u3042\u308b\u304c\uff0c \u3053\u3053\u3067\u306f\u553e\u6db2\u3092\u5410\u304d\u51fa\u3057\u305f\u30b0\u30eb\u30fc\u30d7\uff08spit\uff09\u3068\u553e\u6db2\u3092\u98f2\u3093\u3060\u30b0\u30eb\u30fc\u30d7\uff08swallow\uff09\u3067\u6bd4\u8f03\u3057\u3066\u3044\u308b\u3002\u553e\u6db2\u3092\u98f2\u307f\u8fbc\u3093\u3060\u30b0\u30eb\u30fc\u30d7\u306f\u8840\u6f3f\u4e2d\u306e\u785d\u9178\u5869\u6fc3\u5ea6\u306f\u5909\u308f\u3089\u306a\u3044\u304c\u4e9c\u785d\u9178\u6fc3\u5ea6\u306f\u5927\u304d\u304f\u7570\u306a\u3063\u3066\u3044\u308b\u3002\u785d\u9178\u5869\u304c\u553e\u6db2\u306b\u3088\u308a\u4e9c\u785d\u9178\u5869\u306b\u5909\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3053\u308c\u3067\u3088\u304f\u7406\u89e3\u3067\u304d\u308b\u3002<\/p>\n\n\n\n

\u3000\u56f3\uff19\u306ea\uff5eb\u306f\uff0c\u30d3\u30fc\u30c8\u30b8\u30e5\u30fc\u30b9\u3092\u98f2\u3093\u3060\u4eba\u3068\u98f2\u307e\u306a\u3044\u4eba\u306e\u6bd4\u8f03\u3060\u304c\uff0c\u98f2\u7528\u5f8c\uff13\u6642\u9593\u5f8c\u3067\u30d3\u30fc\u30c8\u30b8\u30e5\u30fc\u30b9\u3092\u98f2\u3093\u3060\u4eba\u306f\u6700\u5927\u8840\u572710.4\u00b13\uff0c\u6700\u5c0f\u8840\u57278.1\u00b12.1\u3068\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3002\u305f\u3060\u3053\u3053\u3067\u30d3\u30fc\u30c8\u30b8\u30e5\u30fc\u30b9\u306e\u8840\u5727\u3078\u306e\u6301\u7d9a\u52b9\u679c\u306f\uff13\u6642\u9593\u5f8c\u304c\u30d4\u30fc\u30af\u306724\u6642\u9593\u3082\u6301\u7d9a\u3057\u306a\u3044\u3053\u3068\u3082\u6ce8\u610f\u3057\u305f\u3044\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

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\u3000\u56f3\uff19\u306e\u53f3\u4e0b\uff08d\uff09\u306f\uff0c\u553e\u6db2\u306e\u5410\u51fa\u6709\u7121\u3060\u304c\uff0c\u4e9c\u785d\u9178\u5869\u3092\u542b\u3080\u553e\u6db2\u3092\u98f2\u307f\u8fbc\u3093\u3060\u4eba\u306f\u660e\u3089\u304b\u306b\u6700\u9ad8\u8840\u5727\uff08\u53ce\u7e2e\u671f\u8840\u5727\uff09\u3082\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3002\u305d\u3057\u3066\uff0c\u56f310\u306f\u30ab\u30d5\u3067\u8155\u3092\u7d5e\u3081\u865a\u8840\u6027\u5185\u76ae\u6a5f\u80fd\u4e0d\u5168\u306e\u6539\u5584\u5ea6\u3092\u307f\u308b\u691c\u67fb\u7d50\u679c\u3067\u3042\u308b\u304c\uff0c\u5bfe\u7167\u7fa4\u306e\u88ab\u9a13\u8005\u3068\u6bd4\u8f03\u3057\u3066\uff0c\u6025\u6027\u865a\u8840\u5f8c\u306e\u6d41\u91cf\u4f9d\u5b58\u6027\u62e1\u5f35\u529b\u306f\uff0c\u7d0430%\u5897\u52a0\u3057\u3066\u3044\u305f\u3002\u3059\u306a\u308f\u3061\uff0c\u30d3\u30fc\u30c8\u30b8\u30e5\u30fc\u30b9\u306e\u98f2\u7528\u5f8c\u306f\uff0c\u8840\u7ba1\u62e1\u5f35\u80fd\u529b\u304c\u660e\u3089\u304b\u306b\u9ad8\u304f\u306a\u3063\u3066\u3044\u305f\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\uff15\uff0e\u91ce\u83dc\u30fb\u679c\u7269\u306e\u6442\u53d6\uff0c\u7279\u306b\u7dd1\u8449\u91ce\u83dc\u6442\u53d6\u304c\u51a0\u72b6\u52d5\u8108\u75be\u60a3\u767a\u751f\u7387\u3092\u4f4e\u4e0b<\/h3>\n\n\n\n

\u3000\u91ce\u83dc\u3084\u679c\u7269\u6442\u53d6\u304c\u5065\u5eb7\u306b\u826f\u3044\u3068\u306e\u75ab\u5b66\u8abf\u67fb\u306f\u591a\u3044\u3002\u7279\u306b\u897f\u6b27\u8af8\u56fd\u306b\u304a\u3051\u308b\u4e3b\u306a\u6b7b\u56e0\u3067\u3042\u308b\u5fc3\u8840\u7ba1\u7cfb\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u3053\u3067\u306f\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u30b0\u30eb\u30fc\u30d7\u304c\u884c\u3063\u305f\u75ab\u5b66\u8abf\u67fb\u306e\u7d50\u679c\u3092\u56f311\u306b\u793a\u3059\u3002\u3053\u306e\u5834\u5408\u306f\u51a0\u72b6\u52d5\u8108\u75be\u60a3\u306e\u767a\u751f\u30ea\u30b9\u30af\u304c\u91ce\u83dc\u30fb\u679c\u7269\u306e\u6442\u53d6\u91cf\u304c\u591a\u304f\u306a\u308b\u307b\u3069\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3002\u305d\u308c\u3092\u8868\uff11\u306b\u793a\u3059\u3088\u3046\u306b\u91ce\u83dc\u3068\u679c\u7269\u5225\uff0c\u91ce\u83dc\u3082\u5c11\u3057\u7d30\u304b\u304f\u5206\u985e\u3057\u76f4\u3057\uff0c\uff11\u30b5\u30fc\u30d3\u30f3\u30b0\uff08\u91ce\u83dc\u306e\u5834\u5408\u306f\u7d0470g\uff09\u3068\u540c\u3058\u91cf\u6442\u53d6\u3057\u305f\u3068\u3059\u308b\u3068\uff0c\u7dd1\u8449\u91ce\u83dc\u304c\u6700\u3082\u51a0\u72b6\u52d5\u8108\u75be\u60a3\u306e\u767a\u751f\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u7387\u304c\u5927\u304d\u3044\u3002\u7dd1\u8449\u91ce\u83dc\u306f\u785d\u9178\u5869\u306e\u542b\u6709\u7387\u304c\u9ad8\u3044\u3002\u3053\u3046\u3057\u305f\u75ab\u5b66\u8abf\u67fb\u3082\u30d3\u30bf\u30df\u30f3\u985e\u3060\u3051\u3067\u306a\u304f\uff0c\u785d\u9178\u5869\u6442\u53d6\u91cf\u3092\u8003\u616e\u306b\u5165\u308c\u3066\uff0c\u8003\u5bdf\u3059\u308b\u6642\u4ee3\u304c\u3044\u305a\u308c\u304f\u308b\u3068\u601d\u3046\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n
\n
\"\"<\/figure><\/div>\n\n\n

\u3000\u305d\u3053\u3067\uff0c\u3053\u3053\u3067\u306f\u3053\u3046\u3057\u305f\u75ab\u5b66\u8abf\u67fb\u7d50\u679c\u3068\u95a2\u9023\u3057\u305f\u5b9f\u9a13\u7d50\u679c\u3092\u7d39\u4ecb\u3059\u308b\u3002Bryan\u3089\uff082007\uff09\u306f\uff0c\u30e9\u30c3\u30c8\u3067\u4e9c\u785d\u9178\u5869\u3084\u785d\u9178\u5869\u542b\u6709\u91cf\u306e\u5c11\u306a\u3044\u98df\u990c\uff08\u3059\u306a\u308f\u3061NOx\u306e\u4e0d\u8db3\uff09\u3092\u4e0e\u3048\u305f\u30de\u30a6\u30b9\u3068\uff0c\u6a19\u6e96\u306e\u98df\u990c\u3068\uff0c\uff17\u65e5\u9593\u785d\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\uff081g\/L\uff09\u306e\u98f2\u6599\u6c34\u3092\u4e0e\u3048\u305f\u30de\u30a6\u30b9\u3067\u306e\u8840\u6f3f\u3084\u5fc3\u81d3\u3067\u306e\u4e9c\u785d\u9178\u5869\uff0c\u785d\u9178\u5869\u6fc3\u5ea6\u3092\u56f312 \u306b\uff0c\u5927\u52d5\u8108\u58ca\u6b7b\u9762\u7a4d\u3068\u5404\u7a2e\u4e00
\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20\u306e\u30bf\u30f3\u30d1\u30af\u91cf\u3092\u6bd4\u8f03\u3057\u305f\u30c7\u30fc\u30bf\u3092\u56f313\u306b\u793a\u3059\u3002NOx\u3092\u307b\u3068\u3093\u3069\u542b\u6709\u3057\u306a\u3044\u98df\u990c\u3092\u6442\u53d6\u3057\u3066\u3044\u308b\u30e9\u30c3\u30c8\u3067\u306f\u8840\u6f3f\u4e2d\u3082\u5fc3\u81d3\u306b\u3082\u4e9c\u785d\u9178\u5869\uff0c\u785d\u9178\u5869\u3068\u3082\u5c11\u306a\u3044\uff08\u56f312) \u3002\u305d\u3057\u3066\uff0c\u5927\u52d5\u8108\u58ca\u6b7b\u9762\u7a4d\u5272\u5408\uff08lnf\/AAR\uff1d\u58ca\u6b7b\/\u5371\u967a\u5fc3\u7b4b\u533a\u57df\uff09\u306f\u6a19\u6e96\u98df\u990c\uff0c\u3042\u308b\u3044\u306f\u785d\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\u6eb6\u6db2\u3092\u6442\u53d6\u3057\u3066\u3044\u305f\u30e9\u30c3\u30c8\u3088\u308a\u660e\u3089\u304b\u306b\u591a\u3044\u3002NOx\u6b20\u4e4f\u30de\u30a6\u30b9\u306f\u6a19\u6e96\u98df\u990c\u306e\u30de\u30a6\u30b9\u306b\u6bd4\u8f03\u3057\u3066\uff0c\u5fc3\u7b4b\u640d\u50b7\u306f59%\u5897\u52a0\u3057\u3066\u3044\u308b\uff08\u56f313\u5de6\u56f3\u306e\u53f3\u4e2d\u592e)\u3002\u30c7\u30fc\u30bf\u306f\u3053\u3053\u306b\u306f\u793a\u3057\u3066\u3044\u306a\u3044\u304c\uff0c\u5fc3\u7b4b\u6897\u585e\u5f8c\u306e\u6b7b\u4ea1\u7387\u308213%\u5897\u52a0\u3057\u3066\u3044\u305f\u3002\u3059\u306a\u308f\u3061\uff0c\u785d\u9178\u3092\u542b\u3080\u98df\u990c\u306f\u5fc3\u7b4b\u6897\u585e\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u306b\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n
\n
\"\"<\/figure><\/div>\n\n\n

\u3000\u306a\u304a\uff0c\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20\uff08NOS\uff09\u306b\u306f\uff0c\uff13\u7a2e\u3042\u308b\u3002\u5185\u76ae\u6027\u306eeNOS\u306f\u539f\u5f62\u8cea\u819c\u3068\u7d50\u5408\u3057\u3066\u3044\u308b\u3002\u795e\u7d4c\u7d30\u80de\u306enNOS\u304a\u3088\u3073\u8a98\u5c0e\u6027iNOS\u306f\u4e3b\u306b\u7d30\u80de\u8cea\u57fa\u8cea\u306b\u5b58\u5728\u3059\u308b\u3002\u3053\u3053\u3067\u306feNOS\u3060\u3051\u304c\u6a19\u6e96\u7684\u98df\u990c\u3067\u3082\u4f4eNOx\u98df\u990c\u3067\u3082\u6052\u5e38\u7684\u306b\u767a\u73fe\u3057\u3066\u3044\u305f\u3002\u7279\u306b\u969b\u7acb\u3063\u305f\u5dee\u7570\u306f\u98df\u990c\u9593\u306b\u8a8d\u3081\u3089\u308c\u3066\u3044\u306a\u3044\u3002\u3057\u305f\u304c\u3063\u3066\uff0c\u56f313\u5de6\u56f3\u306e\u53f3\u7aef\u306e\u58ca\u6b7b\u9762\u7a4d\u306e\u7e2e\u5c0f\u52b9\u679c\u306f\u56f312\u306b\u793a\u3059\u3088\u3046\u306b\u4e9c\u785d\u9178\u5869\u3042\u308b\u3044\u306f\u785d\u9178\u5869\u304b\u3089\u751f\u3058\u305fNO\u306b\u3088\u308b\u52b9\u679c\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n\n\n\n

6. Conclusion<\/h3>\n\n\n\n

\u3000\u91ce\u83dc\u304b\u3089\u6442\u53d6\u3055\u308c\u305f\u785d\u9178\u5869\u306f\uff0c\u553e\u6db2\u4e2d\u30d0\u30af\u30c6\u30ea\u30a2\u306b\u3088\u308a\u4e9c\u785d\u9178\u5869\u306b\u306a\u308a\u4e9c\u785d\u9178\u5869\u306f\u80c3\u306e\u4e2d\u306e\u3088\u3046\u306a\u4f4epH\u4e0b\u3067\u306f\u975e\u9175\u7d20\u7684\u306bNO\u306b\u306a\u308b\u3002\u4ed6\u306e\u4f53\u6db2\u4e2d\u3067\u306f\u56f3\uff12\u306b\u56f3\u793a\u3057\u305f\u3088\u3046\u306b\u4f4e\u9178\u7d20\u6761\u4ef6\u4e0b\u3067NO\u3092\u653e\u51fa\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u3053\u306epH\u304c\u5f37\u9178\u6027\u3067\u306a\u3044\u4e9c\u785d\u9178\u5869\u304b\u3089NO\u3078\u306e\u9084\u5143\u306f\uff0c\u9084\u5143\u578b\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u3084\uff0c\u9084\u5143\u578b\u30df\u30aa\u30b0\u30ed\u30d3\u30f3\uff0c\u30ad\u30b5\u30f3\u30c1\u30f3\u9178\u5316\u9084\u5143\u9175\u7d20\uff0c\u6c34\u7d20\u30a4\u30aa\u30f3\uff0c\u30d3\u30bf\u30df\u30f3C\uff0c\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u304c\u50cd\u3044\u3066\u3044\u308b\u8003\u3048\u3089\u308c\u3066\u3044\u308b\uff08Machha et al\uff0c2012)\u3002In vitro\u5b9f\u9a13\u3060\u304c\uff0c\u4e00\u4f8b\u3092\u56f314\u306b\u793a\u3059\u3002\u4e9c\u785d\u9178\u586920\u03bcM\u3068\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178250\u03bcM\u3092pH7.4\u6761\u4ef6\u4e0b\u3067\u6df7\u5408\u3057\uff0c\u4f4e\u9178\u7d20\u4e0b\u3067pH\u30926.5\u307e\u3067\u5f90\u3005\u306b\u4f4e\u4e0b\u3059\u308b\u3068100nM\u306eNO\u304c\u767a\u751f\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

\u3000\u91ce\u83dc\u306e\u785d\u9178\u5869\u3068\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u306f\u3053\u306e\u3088\u3046\u306b\u5354\u529b\u3057\u3066\u4eba\u4f53\u306b\u6709\u7528\u306aNO\u3092\u751f\u6210\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u306f\u9ad8\u3044\u3002\u91ce\u83dc\u306e\u785d\u9178\u5869\u306f\u4eba\u4f53\u306b\u6709\u76ca\u3067\u3042\u3063\u305f\u3002\u751f\u91cd100g\u5f53\u305f\u308a250mg\u4ee5\u4e0a\u542b\u3080\u91ce\u83dc\u3068\u3057\u3066\uff0c\u30bb\u30ed\u30ea\uff0c\u30af\u30ec\u30bd\u30f3\uff0c\u30ec\u30bf\u30b9\uff0c\u30c0\u30a4\u30b3\u30f3\uff0c\u30ec\u30c3\u30c9\u30d3\u30fc\u30c8\u306e\u6839\uff0c\u30eb\u30c3\u30b3\u30e9\uff0c\u30db\u30a6\u30ec\u30f3\u30bd\u30a6\uff0c\u30d5\u30c0\u30f3\u30bd\u30a6\u306a\u3069\u304c\u4f8b\u793a\u3055\u308c\u3066\u3044\u308b\uff08Machha et al\uff0c2012)\u3002\u3053\u308c\u3089\u306e\u304a\u91ce\u83dc\u3092NO\u306e\u4f5c\u7528\u3082\u8003\u3048\u306a\u304c\u3089\uff0c\u304a\u3044\u3057\u304f\u3044\u305f\u3060\u304d\u307e\u3057\u3087\u3046\uff01<\/p>\n\n\n\n

works cited<\/h3>\n\n\n\n

\u25cfBjorne H\uff0cPetersson J\uff0c[\u2026]\uff0cand Lundberg JO.\uff082004\uff09
\u3000Nitrite in saliva increases gastric mucosal blood flow and mucus thickness. J Clin Invest. 113\uff0c106-114.<\/p>\n\n\n\n

\u25cfBryan NS\uff0cCalvert JW\uff0cElrod JW\uff0cet al.\uff082007\uff09
\u3000Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury. Proc Natl Acad Sci U S A.\uff0c104\uff0c19144-19149.<\/p>\n\n\n\n

\u25cf\u6804\u990a\u6a5f\u80fd\u5316\u5b66\u7814\u7a76\u4f1a\u7de8\uff081996\uff09
\u3000\u6804\u990a\u6a5f\u80fd\u5316\u5b66\u7b2c\uff12\u7248\uff0c\u671d\u5009\u66f8\u5e97<\/p>\n\n\n\n

\u25cfJansson EA\uff0cPetersson J\uff0cReinders C\uff0cSobko T\uff0cBjorne H\uff0cPhillipson M\uff0cWeitzberg E\uff0cHolm L\uff0cLundberg\u3000JO.\uff082007\uff09
\u3000Protection from nonsteroidal antiinflammatory drug\uff08NSAID\uff09-induced gastric ulcers by dietary nitrate. Free Radic Biol Med.15\uff0c\uff1b510-518.<\/p>\n\n\n\n

\u25cfJoshipura KJ\uff0cHu FB\uff0cManson JE\uff0cet al.\uff082001\uff09
\u3000The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med. 134\uff0c1106-1114.<\/p>\n\n\n\n

\u25cfLarsen FJ\uff0cEkblom B\uff0cSahlin K\uff0cet al.\uff082006\uff09
\u3000Effects of dietary nitrate on blood pressure in healthy volunteers. N Engl J Med.355\uff0c2792-2793.<\/p>\n\n\n\n

\u25cfLundberg JO\uff0cWeitzberg E\uff0cLundberg JM\uff0cK Alving\uff081994\uff09
\u3000Intragastric nitric oxide production in humans\uff1ameasurements in expelled air.Gut\uff0c35\uff0c1543-1546.<\/p>\n\n\n\n

\u25cfLundberg JO\uff0cWeitzberg E\uff0cGladwin MT.\uff082008\uff09
\u3000The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 7\uff0c156-167.<\/p>\n\n\n\n

\u25cfMachha A. and Schechter AN.\uff082012\uff09
\u3000Inorganic nitrate\uff1aa major player in the cardio-vascular health benefits of vegetables\uff1fN utrition Reviews. 70\uff0c367-372.<\/p>\n\n\n\n

\u25cfPereira C.\uff0cFerreira NR.\uff0cRocha BS.\uff0cBarbosa RM.\uff0cjinha JL.\uff082013\uff09
\u3000The redox interplay between nitrite and nitric oxide\uff1aFrom the gut to the brain\uff0cRedox Biology\uff0c1\uff0c276-284.<\/p>\n\n\n\n

\u25cf\u6e21\u8fba\u548c\u5f66\u30fb\u5f8c\u85e4\u9038\u7537\u30fb\u5c0f\u5ddd\u5409\u96c4\u30fb\u516d\u672c\u6728\u548c\u592b\uff082012\uff09
\u3000\u74b0\u5883\u30fb\u8cc7\u6e90\u30fb\u5065\u5eb7\u3092\u8003\u3048\u305f\u300c\u571f\u3068\u65bd\u80a5\u306e\u65b0\u77e5\u8b58\u300d\uff0c\u8fb2\u6587\u5354.<\/p>\n\n\n\n

\u25cfWebb AJ. et al.\uff082008\uff09
\u3000Acute Blood Pressure Lowering\uff0cVasoprotective\uff0cand Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite\uff0cHypertension. 51\uff0c784-790.<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

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